In vitro and intracellular activities of LBM415 (NVP PDF-713) against Legionella pneumophila.
نویسندگان
چکیده
LBM415 activity against extracellular and intracellular Legionella pneumophila was studied. The LBM415 MIC50 for 20 Legionella sp. strains was 4 microg/ml, versus 0.06, 0.25, and <or=0.03 microg/ml for azithromycin, erythromycin, and levofloxacin, respectively. LBM415 (0.5 and 16 microg/ml) reversibly prevented intracellular growth of two L. pneumophila strains and was less active than erythromycin.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 6 شماره
صفحات -
تاریخ انتشار 2005